RAD 140 is a selective androgen receptor modulator (SARM)Â currently under development by Radius Health as a product for testosterone replacement therapy capabilities to aid in the treatment of muscle wasting associated with diseases such as cancer. It was first discovered in 2010.
RAD 140 has been shown to carry key benefits attributable to increased testosterone in healthy male subjects and in animal models has been shown to counter the prostate enlargement caused by testosterone use. RAD140 stimulates the levator ani muscle in mouse studies.
In studies in Macaca fascicularis a mean weight gain of greater than 10% in just 28 days of dosing was achieved at a dose of just 0.1 mg/kg, with a similar effect observed at the 1.0 mg/kg dosing group. Through X-ray absorptiometry analysis no consistent effect on absolute fat mass was observed, whereas muscle showed a qualitative trend that increases with dosage. This means that RAD-140 has been shown to increase muscle mass without having a significant impact on fat deposits.
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