MK 677 (Ibutamoren) is a long-acting, orally-active, and selective agonist of the ghrelin receptor. It is a growth hormone secretagogue that mimics the growth hormone stimulating action of the natural hormone ghrelin. Essentially this compound is able to enhance natural growth hormone secretion in subjects resulting in all the benefits that come with this important hormone including muscle growth, repair, and performance capabilities.
Initially developed for use as a treatment for muscle wasting, obesity, and osteoporosis MK 677 has been demonstrated to increase the release of several other hormones including insulin-like growth factor 1 without affecting cortisol levels and been shown to sustain activation of the GH-IGF-1 Axis and increase lean body mass with no change in total fat mass or visceral fat.
Over 12 months it enhanced growth hormone secretion, significantly increased fat-free mass, and was generally well-tolerated amongst the 65 patients in a 2008 clinical study. The results indicate that long-term functional and pharmacoeconomic studies in elderly persons could be beneficial.
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